Article

Pharmacological or genetic inhibition of LTCC promotes cardiomyocyte proliferation through inhibition of calcineurin activity.

2023-11-30

Abstract excerpt

<title>Abstract</title> <p>Cardiomyocytes (CMs) lost during ischemic cardiac injury cannot be replaced due to their limited proliferative capacity, which leads to progressive heart failure. Calcium (Ca2+) is an important signal transducer that regulates key cellular processes, but its role in regulating CM proliferation is incompletely understood. A drug screen targeting proteins involved in CM calcium cycling in...

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Literature Corpus work: 77f091f5-0fb2-52de-b7df-ba09c854bd34
DOI: 10.21203/rs.3.rs-3552794/v1

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