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Article

The fifth essential DNA polymerase phi in Saccharomyces cerevisiae is localized to the nucleolus and plays an important role in synthesis of rRNA.

Proceedings of the National Academy of Sciences of the United States of America - 9 Jul 2002

Shimizu Kikuo, Kawasaki Yasuo, Hiraga Shin-Ichiro, Tawaramoto Maki, Nakashima Naomi, Sugino Akio

Abstract excerpt

We report that POL5 encodes the fifth essential DNA polymerase in Saccharomyces cerevisiae. Pol5p was identified and purified from yeast cell extracts and is an aphidicolin-sensitive DNA polymerase that is stimulated by yeast proliferating cell nuclear antigen (PCNA). Thus, we named Pol5p DNA polymerase phi. Temperature-sensitive pol5-1-- -3 mutants did not arrest at G(2)/M at the restrictive temperature....

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Identifiers

PMID: 12093911
DOI: 10.1073/pnas.142277999
PMCID: PMC123106

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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