Article
Yeast DNA polymerase epsilon participates in leading-strand DNA replication.
Science (New York, N.Y.) - 6 Jul 2007
Pursell Zachary F, Isoz Isabelle, Lundström Else-Britt, Johansson Erik, Kunkel Thomas A
Abstract excerpt
Multiple DNA polymerases participate in replicating the leading and lagging strands of the eukaryotic nuclear genome. Although 50 years have passed since the first DNA polymerase was discovered, the identity of the major polymerase used for leading-strand replication is uncertain. We constructed a derivative of yeast DNA polymerase epsilon that retains high replication activity but has strongly reduced...
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