Article
Synthetic lethal interactions with conditional poly(A) polymerase alleles identify LCP5, a gene involved in 18S rRNA maturation.
RNA (New York, N.Y.) - 1 Nov 1998
Wiederkehr T, Prétôt R F, Minvielle-Sebastia L
Abstract excerpt
To identify new genes involved in 3'-end formation of mRNAs in Saccharomyces cerevisiae, we carried out a screen for synthetic lethal mutants with the conditional poly(A) polymerase allele, pap1-7. Five independent temperature-sensitive mutations called Icp1 to Icp5 (for lethal with conditional p...
Topics
- Alleles
- Amino Acid Sequence
- Basic-Leucine Zipper Transcription Factors
- DNA-Binding Proteins
- Fungal Proteins
- Genes, Essential
- Genes, Fungal
- Genes, Lethal
- Molecular Sequence Data
- Mutagenesis
- Nuclear Proteins
- Pancreatitis-Associated Proteins
- Phenotype
- Polynucleotide Adenylyltransferase
- Polyribosomes
- Protein Biosynthesis
- RNA Processing, Post-Transcriptional
- RNA, Fungal