Article
Structure/function analysis of the Saccharomyces cerevisiae Trf4/Pol sigma DNA polymerase.
Genetics - 1 Feb 2002
Wang Zhenghe, Castaño Irene B, Adams Carrie, Vu Clemence, Fitzhugh David, Christman Michael F
Abstract excerpt
The Trf4p/Pol sigma DNA polymerase (formerly Trf4p/Pol kappa) couples DNA replication to the establishment of sister chromatid cohesion. The polymerase is encoded by two redundant homologs in Saccharomyces cerevisiae, TRF4 and TRF5, that together define a fourth essential nuclear DNA polymerase in yeast and probably in all eukaryotes. Here we present a thorough genetic analysis of the founding member of this...
Topics
- Amino Acid Sequence
- Chromosomal Proteins, Non-Histone
- DNA Repair
- DNA-Directed DNA Polymerase
- Evolution, Molecular
- Molecular Sequence Data
- Mutation
- Nuclear Proteins
- Protein Structure, Tertiary
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Sequence Homology
- Structure-Activity Relationship