Article
PCNA connects DNA replication to epigenetic inheritance in yeast.
Nature - 9 Nov 2000
Zhang Z, Shibahara K, Stillman B
Abstract excerpt
Formation of a heterochromatin-like structure results in transcriptional silencing at the HM mating-type loci and telomeres in Saccharomyces cerevisiae. Once formed, such epigenetically determined structures are inherited for many mitotic divisions. Here we show that mutations in the proliferatin...
Topics
- Carboxy-Lyases
- Chromatin Assembly Factor-1
- Chromosomal Proteins, Non-Histone
- DNA Replication
- DNA, Fungal
- DNA-Binding Proteins
- Gene Expression Regulation, Fungal
- Gene Silencing
- Genes, Fungal
- Genes, Mating Type, Fungal
- Models, Molecular
- Mutation