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Article

PCNA connects DNA replication to epigenetic inheritance in yeast.

Nature - 9 Nov 2000

Zhang Z, Shibahara K, Stillman B

Abstract excerpt

Formation of a heterochromatin-like structure results in transcriptional silencing at the HM mating-type loci and telomeres in Saccharomyces cerevisiae. Once formed, such epigenetically determined structures are inherited for many mitotic divisions. Here we show that mutations in the proliferating cell nuclear antigen (PCNA), an essential component at the DNA replication fork, reduced repression of genes near a...

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Source

Identifiers

PMID: 11089978
DOI: 10.1038/35041601

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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PCNA connects DNA replication to epigenetic inheritance in yeast.PMID 11089978Read ↗

Proliferating cell nuclear antigen (PCNA) is required for cell cycle-regulated silent chromatin on replicated and nonreplicated genes.Semantic proximity Read ↗

Proliferating cell nuclear antigen and ASF1 modulate silent chromatin in Saccharomyces cerevisiae via lysine 56 on histone H3.Semantic proximity Read ↗

A role for the replication proteins PCNA, RF-C, polymerase epsilon and Cdc45 in transcriptional silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

Analysis of epigenetic stability and conversions in Saccharomyces cerevisiae reveals a novel role of CAF-I in position-effect variegation.Semantic proximity Read ↗

γH2A is a component of yeast heterochromatin required for telomere elongation.Semantic proximity Read ↗

Chromatin assembly factor I mutants defective for PCNA binding require Asf1/Hir proteins for silencing.Semantic proximity Read ↗

Positive roles of SAS2 in DNA replication and transcriptional silencing in yeast.Semantic proximity Read ↗

Disturbance of normal cell cycle progression enhances the establishment of transcriptional silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

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CAF-1 in Replication and Repair: A Critical Genetic Mediator of Synthesis-Coupled Nucleosome AssemblySemantic proximity Read ↗

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