Dbp5p/Rat8p is a yeast nuclear pore-associated DEAD-box protein essential for RNA export.

doi:10.1093/emboj/17.9.2663

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Article

Dbp5p/Rat8p is a yeast nuclear pore-associated DEAD-box protein essential for RNA export.

The EMBO journal - 1 May 1998

Snay-Hodge C A, Colot H V, Goldstein A L, Cole C N

Abstract excerpt

To identify Saccharomyces cerevisiae genes important for nucleocytoplasmic export of messenger RNA, we screened mutant strains to identify those in which poly(A)+ RNA accumulated in nuclei under nonpermissive conditions. We describe the identification of DBP5 as the gene defective in the strain c...

Topics

Alleles
Amino Acid Sequence
Animals
Base Sequence
Cloning, Molecular
Cytoplasm
DNA Primers
Databases, Factual
Eukaryotic Initiation Factor-4A
Fungal Proteins
Genes, Fungal
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Molecular Sequence Data

Nuclear Envelope

Peptide Initiation Factors

Peptide Library

RNA Helicases

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Identifiers

PMID: 9564048
DOI: 10.1093/emboj/17.9.2663
PMCID: PMC1170607

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9564048-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Dbp5p/Rat8p is a yeast nuclear pore-associated DEAD-box protein essential for RNA export.PMID 9564048Read ↗

Synthetic genetic array analysis in Saccharomyces cerevisiae provides evidence for an interaction between RAT8/DBP5 and genes encoding P-body components.Semantic proximity Read ↗

An early function during transcription for the yeast mRNA export factor Dbp5p/Rat8p suggested by its genetic and physical interactions with transcription factor IIH components.Semantic proximity Read ↗

Rat8p/Dbp5p is a shuttling transport factor that interacts with Rat7p/Nup159p and Gle1p and suppresses the mRNA export defect of xpo1-1 cells.Semantic proximity Read ↗

Isolation and characterization of RAT1: an essential gene of Saccharomyces cerevisiae required for the efficient nucleocytoplasmic trafficking of mRNA.Semantic proximity Read ↗

Nuclear Export of Pre-Ribosomal Subunits Requires Dbp5, but Not as an RNA-Helicase as for mRNA Export.Semantic proximity Read ↗

Pleiotropic nuclear defects associated with a conditional allele of the novel nucleoporin Rat9p/Nup85p.Semantic proximity Read ↗

The DEAD-box protein Dbp5p is required to dissociate Mex67p from exported mRNPs at the nuclear rim.Semantic proximity Read ↗

Mutation or deletion of the Saccharomyces cerevisiae RAT3/NUP133 gene causes temperature-dependent nuclear accumulation of poly(A)+ RNA and constitutive clustering of nuclear pore complexes.Semantic proximity Read ↗

Nuclear pore complex clustering and nuclear accumulation of poly(A)+ RNA associated with mutation of the Saccharomyces cerevisiae RAT2/NUP120 gene.Semantic proximity Read ↗

The RNA export factor Gle1p is located on the cytoplasmic fibrils of the NPC and physically interacts with the FG-nucleoporin Rip1p, the DEAD-box protein Rat8p/Dbp5p and a new protein Ymr 255p.Semantic proximity Read ↗

A nuclear 3'-5' exonuclease involved in mRNA degradation interacts with Poly(A) polymerase and the hnRNA protein Npl3p.Semantic proximity Read ↗

Rrp8p is a yeast nucleolar protein functionally linked to Gar1p and involved in pre-rRNA cleavage at site A2.Semantic proximity Read ↗

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