Article
Characterization of Ca2+/calmodulin-dependent protein kinase I as a myosin II regulatory light chain kinase in vitro and in vivo.
The Biochemical journal - 15 Oct 2002
Suizu Futoshi, Fukuta Yasuaki, Ueda Kozue, Iwasaki Takahiro, Tokumitsu Hiroshi, Hosoya Hiroshi
Abstract excerpt
Ca(2+)/calmodulin (CaM)-dependent protein kinase I (CaM-KI), which is a member of the multifunctional CaM-K family, is thought to be involved in various Ca(2+)-signalling pathways. In this report, we demonstrate that CaM-KI activated by an upstream kinase (CaM-K kinase), but not unactivated CaM-KI, phosphorylates myosin II regulatory light chain (MRLC) efficiently ( K (cat), 1.7 s(-1)) and stoichiometrically...
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