Article
Cell cycle regulation of myosin-V by calcium/calmodulin-dependent protein kinase II.
Science (New York, N.Y.) - 17 Aug 2001
Karcher R L, Roland J T, Zappacosta F, Huddleston M J, Annan R S, Carr S A, Gelfand V I
Abstract excerpt
Organelle transport by myosin-V is down-regulated during mitosis, presumably by myosin-V phosphorylation. We used mass spectrometry phosphopeptide mapping to show that the tail of myosin-V was phosphorylated in mitotic Xenopus egg extract on a single serine residue localized in the carboxyl-terminal organelle-binding domain. Phosphorylation resulted in the release of the motor from the organelle. The...
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