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Article

Multifunctional Ca2+/calmodulin-dependent protein kinase made Ca2+ independent for functional studies.

Biochemistry - 20 Feb 1990

Waldmann R, Hanson P I, Schulman H

Abstract excerpt

Multifunctional Ca2+/calmodulin-dependent protein kinase (CaM kinase) that is transiently expressed in COS-7 cells is essentially inactive when assayed without Ca2+. Physiological activation of the kinase occurs by binding of Ca2+/calmodulin near a putative autoinhibitory subdomain that contains the sequence His282-Arg-Gln-Glu-Thr286. We have markedly increased the Ca2(+)-independent activity of CaM kinase by...

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PMID: 2158811
DOI: 10.1021/bi00459a002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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