Article
Integrin-linked kinase is a functional Mn2+-dependent protein kinase that regulates glycogen synthase kinase-3β (GSK-3beta) phosphorylation.
PloS one - 23 Aug 2010
Maydan Mykola, McDonald Paul C, Sanghera Jasbinder, Yan Jun, Rallis Charalampos, Pinchin Sheena, Hannigan Gregory E, Foster Leonard J, Ish-Horowicz David, Walsh Michael P, Dedhar Shoukat
Abstract excerpt
BACKGROUND: Integrin-linked kinase (ILK) is a highly evolutionarily conserved, multi-domain signaling protein that localizes to focal adhesions, myofilaments and centrosomes where it forms distinct multi-protein complexes to regulate cell adhesion, cell contraction, actin cytoskeletal organization and mitotic spindle assembly. Numerous studies have demonstrated that ILK can regulate the phosphorylation of various...
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