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Article

Emerging models of glutamate receptor ion channel structure and function.

Structure (London, England : 1993) - 12 Oct 2011

Mayer Mark L

Abstract excerpt

Excitatory synaptic transmission in the brain is mediated by ligand-gated ion channels (iGluRs) activated by glutamate. Distinct from other neurotransmitter receptors, the extracellular domains of iGluRs are loosely packed assemblies with two clearly distinct layers, each of which has both local and global 2-fold axes of symmetry. By contrast, the iGluR transmembrane segments have 4-fold symmetry and share a...

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Identifiers

PMID: 22000510
DOI: 10.1016/j.str.2011.08.009
PMCID: PMC3197216

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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