Article
Domain organization and function in GluK2 subtype kainate receptors.
Proceedings of the National Academy of Sciences of the United States of America - 4 May 2010
Das Utpal, Kumar Janesh, Mayer Mark L, Plested Andrew J R
Abstract excerpt
Glutamate receptor ion channels (iGluRs) are excitatory neurotransmitter receptors with a unique molecular architecture in which the extracellular domains assemble as a dimer of dimers. The structure of individual dimer assemblies has been established previously for both the isolated ligand-bindi...
Topics
- Animals
- Cell Line
- Crystallography, X-Ray
- Humans
- Ion Channel Gating
- Ligands
- Models, Molecular
- Mutation
- Protein Multimerization
- Protein Structure, Quaternary
- Protein Structure, Tertiary
- Rats