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Article

Arrangement of subunits in functional NMDA receptors.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 3 Aug 2011

Salussolia Catherine L, Prodromou Michael L, Borker Priya, Wollmuth Lonnie P

Abstract excerpt

Ionotropic glutamate receptors (iGluRs), including the NMDA receptor subtype, are ligand-gated ion channels critical to fast signaling in the CNS. NMDA receptors are obligate heterotetramers composed of two GluN1 and typically two GluN2 subunits. However, the arrangement of GluN subunits in functional receptors-whether like subunits are adjacent to (N1/N1/N2/N2) or diagonal to (N1/N2/N1/N2) one another-remains...

Topics

4-Aminopyridine
Amino Acid Motifs
Analysis of Variance
Animals
Cell Line, Transformed
Copper Sulfate
Cysteine
Electric Stimulation
Excitatory Amino Acid Agents
Excitatory Amino Acid Antagonists

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Glutamic Acid

Glycine

Humans

Kynurenic Acid

Membrane Potentials

Microinjections

Models, Molecular

Mutagenesis

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Identifiers

PMID: 21813689
DOI: 10.1523/JNEUROSCI.5612-10.2011
PMCID: PMC3207322

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-21813689-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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