Article
Multiple manifestations of X-ray-induced genomic instability in Chinese hamster ovary (CHO) cells.
Molecular carcinogenesis - 1 Nov 2001
Romney C A, Paulauskis J D, Nagasawa H, Little J B
Abstract excerpt
Carcinogenesis is postulated to follow a multistep cascade in which the first genetic event may destabilize cells and thereby facilitate the induction of subsequent mutations within the same cell. It has recently been shown that exposure to ionizing radiation can in itself induce a persistent, heritable genetic instability in cells. To further investigate this phenomenon, we utilized a mutationally unstable...
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