Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Homologous and Nonhomologous Recombination Resulting in Deletion: Effects of p53 Status, Microhomology, and Repetitive DNA Length and Orientation

1 Jun 2000

Abstract excerpt

Repetitive DNA elements frequently are precursors to chromosomal deletions in prokaryotes and lower eukaryotes. However, little is known about the relationship between repeated sequences and deletion formation in mammalian cells. We have created a novel integrated plasmid-based recombination assay to investigate repeated sequence instability in human cells. In a control cell line, the presence of direct or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to CRISPR and Genetic Engineering
Share to DNA Repair Mechanisms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10805745
DOI: 10.1128/mcb.20.11.4028-4035.2000

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Homologous and Nonhomologous Recombination Resulting in Deletion: Effects of p53 Status, Microhomology, and Repetitive DNA Length and OrientationPMID 10805745Read ↗

Short direct repeats flanking deletions, and duplicating insertions in p53 gene in human cancers.Semantic proximity Read ↗

Radiation-induced genomic instability in tandem repeat sequences is not predictive of unique sequence instability.Semantic proximity Read ↗

Indirect mechanisms of genomic instability and the biological significance of mutations at tandem repeat loci.Semantic proximity Read ↗

Genomic deletions created upon LINE-1 retrotransposition.Semantic proximity Read ↗

Increase of spontaneous intrachromosomal homologous recombination in mammalian cells expressing a mutant p53 protein.Semantic proximity Read ↗

New mammalian cellular systems to study mutations introduced at the break site by non-homologous end-joining.Semantic proximity Read ↗

Z-DNA-forming sequences generate large-scale deletions in mammalian cells.Semantic proximity Read ↗

Relative rates of insertion and deletion mutations in a microsatellite sequence in cultured cells.Semantic proximity Read ↗

Altered replication and inverted repeats induce mismatch repair-independent recombination between highly diverged DNAs in yeast.Semantic proximity Read ↗

The role of recombinational hotspots in genome instability in mammalian cells.Semantic proximity Read ↗

Deletion mutations in the hprt gene of T-lymphocytes as a biomarker for genomic rearrangements important in human cancers.Semantic proximity Read ↗

The myotonic dystrophy type 1 triplet repeat sequence induces gross deletions and inversions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.