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Article

Single base-pair deletions induced by bleomycin at potential double-strand cleavage sites in the aprt gene of stationary phase Chinese hamster ovary D422 cells.

Journal of molecular biology - 21 Oct 1994

Povirk L F, Bennett R A, Wang P, Swerdlow P S, Austin M J

Abstract excerpt

One possible mechanism for the generation of deletion mutations is inaccurate repair of DNA double-strand breaks. In an attempt to detect such aberrant repair events in intact cells, confluent stationary phase cultures of chinese hamster ovary D422 cells, which are hemizygous for aprt, were treat...

Topics

Adenine Phosphoribosyltransferase
Animals
Base Sequence
Bleomycin
CHO Cells
Cricetinae
Cricetulus
DNA Repair
G1 Phase
Models, Genetic
Molecular Sequence Data
Mutagenesis, Site-Directed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Nucleosomes

Resting Phase, Cell Cycle

Sequence Deletion

Source

Identifiers

PMID: 7523683
DOI: 10.1006/jmbi.1994.1649

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7523683-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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