Article
Chromosomal destabilization during gene amplification.
Molecular and cellular biology - 1 Jun 1990
Ruiz J C, Wahl G M
Abstract excerpt
Acentric extrachromosomal elements, such as submicroscopic autonomously replicating circular molecules (episomes) and double minute chromosomes, are common early, and in some cases initial, intermediates of gene amplification in many drug-resistant and tumor cell lines. In order to gain a more co...
Topics
- Animals
- Base Sequence
- Cell Line
- Chromosome Aberrations
- Chromosome Deletion
- Chromosome Disorders
- Cricetinae
- Escherichia coli
- Flow Cytometry
- Gene Amplification
- Genes, Bacterial
- Genetic Variation
- Models, Genetic
- Molecular Sequence Data
- Multigene Family
- Nucleic Acid Hybridization
- Oligonucleotide Probes
- Polymerase Chain Reaction