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Article

Chromosomal destabilization during gene amplification.

Molecular and cellular biology - 1 Jun 1990

Ruiz J C, Wahl G M

Abstract excerpt

Acentric extrachromosomal elements, such as submicroscopic autonomously replicating circular molecules (episomes) and double minute chromosomes, are common early, and in some cases initial, intermediates of gene amplification in many drug-resistant and tumor cell lines. In order to gain a more complete understanding of the amplification process, we investigated the molecular mechanisms by which such...

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Identifiers

PMID: 2188107
DOI: 10.1128/mcb.10.6.3056-3066.1990
PMCID: PMC360670

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