Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Two mcm3 mutations affect different steps in the initiation of DNA replication.

The Journal of biological chemistry - 23 Aug 2002

Lei Ming, Cheng Irene H, Roberts Louis A, McAlear Michael A, Tye Bik K

Abstract excerpt

Mcm3 is a subunit of the hexameric MCM2-7 complex required for the initiation and elongation of DNA replication in eukaryotes. We have characterized two mutant alleles, mcm3-1 and mcm3-10, in Saccharomyces cerevisiae and showed that they are defective at different steps of the replication initiation process. Mcm3-10 contains a P118L substitution that compromises its interaction with Mcm5 and the recruitment of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Cell Cycle Proteins
Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Replication

Share to Nuclear Proteins

Share to S Phase

Share to Saccharomyces cerevisiae Proteins

Share to Schizosaccharomyces pombe Proteins

Source

Identifiers

PMID: 12060653
DOI: 10.1074/jbc.M201816200

Genes

MCM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Two mcm3 mutations affect different steps in the initiation of DNA replication.PMID 12060653Read ↗

A lesion in the DNA replication initiation factor Mcm10 induces pausing of elongation forks through chromosomal replication origins in Saccharomyces cerevisiae.Semantic proximity Read ↗

Budding yeast mcm10/dna43 mutant requires a novel repair pathway for viability.Semantic proximity Read ↗

Structural changes in Mcm5 protein bypass Cdc7-Dbf4 function and reduce replication origin efficiency in Saccharomyces cerevisiae.Semantic proximity Read ↗

Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins.Semantic proximity Read ↗

Characterization of Schizosaccharomyces pombe mcm7(+) and cdc23(+) (MCM10) and interactions with replication checkpoints.Semantic proximity Read ↗

Alternative mechanisms for coordinating polymerase alpha and MCM helicase.Semantic proximity Read ↗

The Mcm2-7-interacting domain of human mini-chromosome maintenance 10 (Mcm10) protein is important for stable chromatin association and origin firing.Semantic proximity Read ↗

Mcm10 mediates the interaction between DNA replication and silencing machineries.Semantic proximity Read ↗

The phenotype of the minichromosome maintenance mutant mcm3 is characteristic of mutants defective in DNA replication.Semantic proximity Read ↗

Functional screen of human MCM2-7 variant alleles for disease-causing potential.Semantic proximity Read ↗

The essential schizosaccharomyces pombe cdc23 DNA replication gene shares structural and functional homology with the Saccharomyces cerevisiae DNA43 (MCM10) gene.Semantic proximity Read ↗

Multiple functions for Drosophila Mcm10 suggested through analysis of two Mcm10 mutant alleles.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.