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Article

ER-golgi traffic is a prerequisite for efficient ER degradation.

Molecular biology of the cell - 1 Jun 2002

Taxis Christof, Vogel Frank, Wolf Dieter H

Abstract excerpt

Protein quality control is an essential function of the endoplasmic reticulum. Misfolded proteins unable to acquire their native conformation are retained in the endoplasmic reticulum, retro-translocated back into the cytosol, and degraded via the ubiquitin-proteasome system. We show that efficient degradation of soluble malfolded proteins in yeast requires a fully competent early secretory pathway. Mutations in...

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Identifiers

PMID: 12058050
DOI: 10.1091/mbc.01-08-0399
PMCID: PMC117605

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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