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Article

Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation.

Nature - 28 Aug 1997

Plemper R K, Böhmler S, Bordallo J, Sommer T, Wolf D H

Abstract excerpt

Proteins enter the secretory pathway through the endoplasmic reticulum, which delivers properly folded proteins to their site of action and contains a quality-control system to monitor and prevent abnormal proteins from being delivered. Many of these proteins are degraded by the cytoplasmic proteasome, which requires their retrograde transport to the cytoplasm. Based on a co-immunoprecipitation of major...

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Identifiers

PMID: 9278052
DOI: 10.1038/42276

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation.PMID 9278052Read ↗

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Distinct domains within yeast Sec61p involved in post-translational translocation and protein dislocation.Semantic proximity Read ↗

Multiple endoplasmic reticulum-associated pathways degrade mutant yeast carboxypeptidase Y in mammalian cells.Semantic proximity Read ↗

Genetic interactions of Hrd3p and Der3p/Hrd1p with Sec61p suggest a retro-translocation complex mediating protein transport for ER degradation.Semantic proximity Read ↗

Interplay of substrate retention and export signals in endoplasmic reticulum quality control.Semantic proximity Read ↗

The Sec63p J-domain is required for ERAD of soluble proteins in yeast.Semantic proximity Read ↗

Protein transport into the endoplasmic reticulum: mechanisms and pathologies.Semantic proximity Read ↗

Der3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins.Semantic proximity Read ↗

Endoplasmic reticulum-associated protein quality control and degradation: screen for ERAD mutants after ethylmethane sulfonate mutagenesis.Semantic proximity Read ↗

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