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Article

A RING-H2 finger motif is essential for the function of Der3/Hrd1 in endoplasmic reticulum associated protein degradation in the yeast Saccharomyces cerevisiae.

FEBS letters - 9 Apr 1999

Bordallo J, Wolf D H

Abstract excerpt

Der3/Hrd1p is a protein required for proper degradation of misfolded soluble and integral membrane proteins in the endoplasmic reticulum (ER) in the yeast Saccharomyces cerevisiae. It is located to the ER membrane and consists of a N-terminal hydrophobic region with several transmembrane domains...

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Identifiers

PMID: 10218484
DOI: 10.1016/s0014-5793(99)00362-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10218484-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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A RING-H2 finger motif is essential for the function of Der3/Hrd1 in endoplasmic reticulum associated protein degradation in the yeast Saccharomyces cerevisiae.PMID 10218484Read ↗

Der3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins.Semantic proximity Read ↗

Genetic interactions of Hrd3p and Der3p/Hrd1p with Sec61p suggest a retro-translocation complex mediating protein transport for ER degradation.Semantic proximity Read ↗

The interplay of Hrd3 and the molecular chaperone system ensures efficient degradation of malfolded secretory proteins.Semantic proximity Read ↗

ER-golgi traffic is a prerequisite for efficient ER degradation.Semantic proximity Read ↗

A positive genetic selection for transmembrane domain mutations in HRD1 underscores the importance of Hrd1 complex integrity during ERAD.Semantic proximity Read ↗

A genomic screen identifies Dsk2p and Rad23p as essential components of ER-associated degradation.Semantic proximity Read ↗

Yeast Derlin Dfm1 interacts with Cdc48 and functions in ER homeostasis.Semantic proximity Read ↗

Identification of SEC12, SED4, truncated SEC16, and EKS1/HRD3 as multicopy suppressors of ts mutants of Sar1 GTPase.Semantic proximity Read ↗

Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation.Semantic proximity Read ↗

Defective ER associated degradation of a model luminal substrate in yeast carrying a mutation in the 4th ER luminal loop of Sec61p.Semantic proximity Read ↗

Endoplasmic reticulum-associated protein quality control and degradation: screen for ERAD mutants after ethylmethane sulfonate mutagenesis.Semantic proximity Read ↗

PRB1 is required for clipping of the histone H3 N terminal tail in Saccharomyces cerevisiae.Semantic proximity Read ↗

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