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Article

Stress tolerance of misfolded carboxypeptidase Y requires maintenance of protein trafficking and degradative pathways.

Molecular biology of the cell - 1 Jul 2003

Spear Eric D, Ng Davis T W

Abstract excerpt

The accumulation of aberrantly folded proteins can lead to cell dysfunction and death. Currently, the mechanisms of toxicity and cellular defenses against their effects remain incompletely understood. In the endoplasmic reticulum (ER), stress caused by misfolded proteins activates the unfolded protein response (UPR). The UPR is an ER-to-nucleus signal transduction pathway that regulates a wide variety of target...

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Identifiers

PMID: 12857862
DOI: 10.1091/mbc.e02-11-0717
PMCID: PMC165674

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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