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Article

Genetic interactions of Hrd3p and Der3p/Hrd1p with Sec61p suggest a retro-translocation complex mediating protein transport for ER degradation.

Journal of cell science - 1 Nov 1999

Plemper R K, Bordallo J, Deak P M, Taxis C, Hitt R, Wolf D H

Abstract excerpt

The endoplasmic reticulum contains a quality control system that subjects misfolded or unassembled secretory proteins to rapid degradation via the cytosolic ubiquitin proteasome system. This requires retrograde protein transport from the endoplasmic reticulum back to the cytosol. The Sec61 pore, the central component of the protein import channel into the endoplasmic reticulum, was identified as the core subunit...

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Source

Identifiers

PMID: 10547371
DOI: 10.1242/jcs.112.22.4123

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic interactions of Hrd3p and Der3p/Hrd1p with Sec61p suggest a retro-translocation complex mediating protein transport for ER degradation.PMID 10547371Read ↗

Der3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins.Semantic proximity Read ↗

A RING-H2 finger motif is essential for the function of Der3/Hrd1 in endoplasmic reticulum associated protein degradation in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

The interplay of Hrd3 and the molecular chaperone system ensures efficient degradation of malfolded secretory proteins.Semantic proximity Read ↗

ER-golgi traffic is a prerequisite for efficient ER degradation.Semantic proximity Read ↗

Sec61p is required for ERAD-L: genetic dissection of the translocation and ERAD-L functions of Sec61P using novel derivatives of CPY.Semantic proximity Read ↗

Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation.Semantic proximity Read ↗

Der1 promotes movement of misfolded proteins through the endoplasmic reticulum membrane.Semantic proximity Read ↗

Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation.Semantic proximity Read ↗

The Sec63p J-domain is required for ERAD of soluble proteins in yeast.Semantic proximity Read ↗

A positive genetic selection for transmembrane domain mutations in HRD1 underscores the importance of Hrd1 complex integrity during ERAD.Semantic proximity Read ↗

Endoplasmic reticulum-associated protein quality control and degradation: screen for ERAD mutants after ethylmethane sulfonate mutagenesis.Semantic proximity Read ↗

Ssh1p determines the translocation and dislocation capacities of the yeast endoplasmic reticulum.Semantic proximity Read ↗

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