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Article

Consequences of mutations in the genes of the ER export machinery COPII in vertebrates.

Cell stress & chaperones - 1 Mar 2020

Lu Chung-Ling, Kim Jinoh

Abstract excerpt

Coat protein complex II (COPII) plays an essential role in the export of cargo molecules such as secretory proteins, membrane proteins, and lipids from the endoplasmic reticulum (ER). In yeast, the COPII machinery is critical for cell viability as most COPII knockout mutants fail to survive. In mice and fish, homozygous knockout mutants of most COPII genes are embryonic lethal, reflecting the essentiality of the...

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PMID: 31970693
DOI: 10.1007/s12192-019-01062-3
PMCID: PMC7058761

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Consequences of mutations in the genes of the ER export machinery COPII in vertebrates.PMID 31970693Read ↗

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Mutant PLP1 impairs COPII vesicle formation via ER calcium depletion in Pelizaeus-Merzbacher disease.Semantic proximity Read ↗

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