The medial-Golgi ion pump Pmr1 supplies the yeast secretory pathway with Ca2+ and Mn2+ required for glycosylation, sorting, and endoplasmic reticulum-associated protein degradation.

doi:10.1091/mbc.9.5.1149

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Article

The medial-Golgi ion pump Pmr1 supplies the yeast secretory pathway with Ca2+ and Mn2+ required for glycosylation, sorting, and endoplasmic reticulum-associated protein degradation.

Molecular biology of the cell - 1 May 1998

Dürr G, Strayle J, Plemper R, Elbs S, Klee S K, Catty P, Wolf D H, Rudolph H K

Abstract excerpt

The yeast Ca2+ adenosine triphosphatase Pmr1, located in medial-Golgi, has been implicated in intracellular transport of Ca2+ and Mn2+ ions. We show here that addition of Mn2+ greatly alleviates defects of pmr1 mutants in N-linked and O-linked protein glycosylation. In contrast, accurate sorting...

Topics

Calcium
Calcium-Transporting ATPases
Cations, Divalent
Culture Media
Egtazic Acid
Endoplasmic Reticulum
Fungal Proteins
Glycosylation
Golgi Apparatus
Manganese
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plasma Membrane Calcium-Transporting ATPases

Receptors, Cell Surface

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Vacuoles

Vesicular Transport Proteins

Source

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Identifiers

PMID: 9571246
DOI: 10.1091/mbc.9.5.1149
PMCID: PMC25337

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9571246-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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