Article
Der3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins.
Molecular biology of the cell - 1 Jan 1998
Bordallo J, Plemper R K, Finger A, Wolf D H
Abstract excerpt
We have studied components of the endoplasmic reticulum (ER) proofreading and degradation system in the yeast Saccharomyces cerevisiae. Using a der3-1 mutant defective in the degradation of a mutated lumenal protein, carboxypeptidase yscY (CPY*), a gene was cloned which encodes a 64-kDa protein o...
Topics
- Amino Acid Sequence
- Base Sequence
- Carboxypeptidases
- Cathepsin A
- Cell Division
- Cloning, Molecular
- Endoplasmic Reticulum
- Fungal Proteins
- Gene Deletion
- Intracellular Membranes
- Ligases
- Membrane Proteins
- Membrane Transport Proteins
- Molecular Sequence Data
- Mutation
- Protein Folding
- Proteins
- SEC Translocation Channels