Article
Increased genetic susceptibility to renal damage in the stroke-prone spontaneously hypertensive rat.
Kidney international - 1 May 2002
Churchill Paul C, Churchill Monique C, Griffin Karen A, Picken Maria, Webb Robert Clinton, Kurtz Theodore W, Bidani Anil K
Abstract excerpt
BACKGROUND: The spontaneously hypertensive rat (SHR) develops much less renal damage than the stroke-prone strain of SHR (SHRsp) after salt-supplementation, and it has been proposed that these strains differ in their genetic susceptibility to renal damage. However, radiotelemetric BP measurements have shown that salt-supplementation results in more severe and accelerated hypertension in the SHRsp. Therefore, it...
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