Article
Heterogeneous stock rats: a new model to study the genetics of renal phenotypes.
American journal of physiology. Renal physiology - 1 Jun 2010
Solberg Woods Leah C, Stelloh Cary, Regner Kevin R, Schwabe Tiffany, Eisenhauer Jessica, Garrett Michael R
Abstract excerpt
Chronic kidney disease is a growing medical concern, with an estimated 25.6 million people in the United States exhibiting some degree of kidney injury and/or decline in kidney function. Animal models provide great insight into the study of the genetics of complex diseases. In particular, heterogeneous stock (HS) rats represent a unique genetic resource enabling rapid fine-mapping of complex traits. However, they...
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