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Article

Geno-transcriptomic dissection of proteinuria in the uninephrectomized rat uncovers a molecular complexity with sexual dimorphism.

Physiological genomics - 29 Nov 2010

Yagil Yoram, Hessner Martin, Schulz Herbert, Gosele Claudia, Lebedev Larissa, Barkalifa Ronit, Sapojnikov Marina, Hubner Norbert, Yagil Chana

Abstract excerpt

Investigation of proteinuria, whose pathophysiology remains incompletely understood, is confounded by differences in the phenotype between males and females. We initiated a sex-specific geno-transcriptomic dissection of proteinuria in uninephrectomized male and female Sabra rats that spontaneously develop focal and segmental glomerulosclerosis, testing the hypothesis that different mechanisms might underlie the...

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PMID: 20876844
DOI: 10.1152/physiolgenomics.00149.2010

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