Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Establishment and Maintenance of Genomic Methylation Patterns in Mouse Embryonic Stem Cells by Dnmt3a and Dnmt3b

31 Jul 2003

Abstract excerpt

We have previously shown that the DNA methyltransferases Dnmt3a and Dnmt3b carry out de novo methylation of the mouse genome during early postimplantation development and of maternally imprinted genes in the oocyte. In the present study, we demonstrate that Dnmt3a and Dnmt3b are also essential for the stable inheritance, or "maintenance," of DNA methylation patterns. Inactivation of both Dnmt3a and Dnmt3b in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Genetic Syndromes and Imprinting
Share to Prenatal Screening and Diagnostics

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12897133
DOI: 10.1128/mcb.23.16.5594-5605.2003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Establishment and Maintenance of Genomic Methylation Patterns in Mouse Embryonic Stem Cells by Dnmt3a and Dnmt3bPMID 12897133Read ↗

Mammalian (cytosine-5) methyltransferases cause genomic DNA methylation and lethality in Drosophila.Semantic proximity Read ↗

Identification of a region of the DNMT1 methyltransferase that regulates the maintenance of genomic imprints.Semantic proximity Read ↗

Rescuing DNMT1 Fails to Fully Reverse the Molecular and Functional Repercussions of Its Loss in Mouse Embryonic Stem CellsSemantic proximity Read ↗

Dynamic instability of genomic methylation patterns in pluripotent stem cellsSemantic proximity Read ↗

DNA methylation dynamics of genomic imprinting in mouse development†Semantic proximity Read ↗

Non-canonical functions of DNMT3A in hematopoietic stem cells regulate telomerase activity and genome integritySemantic proximity Read ↗

Base-Resolution Analysis of DNA Methylation Patterns Downstream of Dnmt3a in Mouse Naïve B Cells.Semantic proximity Read ↗

Dnmt3b recruitment through E2F6 transcriptional repressor mediates germ-line gene silencing in murine somatic tissuesSemantic proximity Read ↗

Role of the Dnmt3 family in de novo methylation of imprinted and repetitive sequences during male germ cell development in the mouseSemantic proximity Read ↗

Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting.Semantic proximity Read ↗

Dnmt3a is essential for hematopoietic stem cell differentiation.Semantic proximity Read ↗

Developmental genome-wide DNA methylation asymmetry between mouse placenta and embryoSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.