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Article

Biological functions of DNA methyltransferase 1 require its methyltransferase activity.

Molecular and cellular biology - 1 Jun 2007

Damelin Marc, Bestor Timothy H

Abstract excerpt

DNA methyltransferase 1 (DNMT1) has been reported to interact with a wide variety of factors and to contain intrinsic transcriptional repressor activity. When a conservative point mutation was introduced at the key catalytic residue, mutant DNMT1 failed to rescue any of the phenotypes of Dnmt1-null embryonic stem (ES) cells, which indicated that the biological functions of DNMT1 are exerted through the...

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Source

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Identifiers

PMID: 17371843
DOI: 10.1128/MCB.00036-07
PMCID: PMC1900033

Genes

DNMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Biological functions of DNA methyltransferase 1 require its methyltransferase activity.PMID 17371843Read ↗

Rescuing DNMT1 Fails to Fully Reverse the Molecular and Functional Repercussions of Its Loss in Mouse Embryonic Stem CellsSemantic proximity Read ↗

DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells.Semantic proximity Read ↗

Mammalian (cytosine-5) methyltransferases cause genomic DNA methylation and lethality in Drosophila.Semantic proximity Read ↗

Identification of a region of the DNMT1 methyltransferase that regulates the maintenance of genomic imprints.Semantic proximity Read ↗

Major and essential role for the DNA methylation mark in mouse embryogenesis and stable association of DNMT1 with newly replicated regions.Semantic proximity Read ↗

Mouse embryonic stem cells exhibit cancer-like DNA methylation landscapes upon DNMT1 overexpressionSemantic proximity Read ↗

DNMT1 can induce primary germ layer differentiation through de novo DNA methylationSemantic proximity Read ↗

SUMOylation enhances DNA methyltransferase 1 activity.Semantic proximity Read ↗

Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation.Semantic proximity Read ↗

DNMT1 overexpression disrupts DNA methylation homeostasis in mouse embryonic stem cellsSemantic proximity Read ↗

Identification of genetic elements that autonomously determine DNA methylation states.Semantic proximity Read ↗

DNMT1 modulates gene expression without its catalytic activity partially through its interactions with histone-modifying enzymes.Semantic proximity Read ↗

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