Mutation of CpGs in the murine stem cell virus retroviral vector long terminal repeat represses silencing in embryonic stem cells.

doi:10.1074/jbc.M309128200

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Article

Mutation of CpGs in the murine stem cell virus retroviral vector long terminal repeat represses silencing in embryonic stem cells.

The Journal of biological chemistry - 2 Jan 2004

Swindle C Scott, Kim Hyung G, Klug Christopher A

Abstract excerpt

Although DNA methylation and transcriptional repression are generally associated, a causal role for DNA methylation in silencing of retroviral vectors has not been established. The newer generation murine stem cell virus retroviral vector (MSCV) lacks many of the repressive cis-acting DNA sequences identified in Moloney murine leukemia virus but remains sensitive to transcriptional silencing in various cell...

Topics

Animals
Base Sequence
DNA Primers
Dinucleoside Phosphates
Gene Silencing
Genes, Reporter
Genetic Vectors
Green Fluorescent Proteins
Humans
Luminescent Proteins
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Retroviridae

Stem Cells

Terminal Repeat Sequences

Transcription, Genetic

Transcriptional Activation

Source

Open in PubMed

Identifiers

PMID: 14559924
DOI: 10.1074/jbc.M309128200

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