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NS1-mediated DNMT1 degradation regulates human bocavirus 1 replication and RNA processing

14 Nov 2024

Abstract excerpt

Methylation of the DNA genome plays an important role in viral gene inactivation. However, the role of DNA methylation in human bocavirus (HBoV) remains unclear. In this study, the HBoV1 genomic DNA was found extensively methylated at the CHG and CHH sites. Inhibiting DNA methylation with 5-aza-2'-deoxycytidine (DAC) altered the methylation status and reduced viral DNA production, while enhanced the RNA splicing...

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PMID: 39541416
DOI: 10.1371/journal.ppat.1012682

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