DNA hypomethylation leads to elevated mutation rates.

doi:10.1038/25779

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Article

DNA hypomethylation leads to elevated mutation rates.

Nature - 3 Sept 1998

Chen R Z, Pettersson U, Beard C, Jackson-Grusby L, Jaenisch R

Abstract excerpt

Genome-wide demethylation has been suggested to be a step in carcinogenesis. Evidence for this notion comes from the frequently observed global DNA hypomethylation in tumour cells, and from a recent study suggesting that defects in DNA methylation might contribute to the genomic instability of so...

Topics

Animals
Blotting, Southern
Cell Line
DNA
DNA (Cytosine-5-)-Methyltransferases
DNA Methylation
Herpes Simplex
Hypoxanthine Phosphoribosyltransferase
Male
Mice
Mice, Inbred C57BL
Mutation
Polymerase Chain Reaction
Stem Cells
Thymidine Kinase

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