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Article

DNA hypomethylation leads to elevated mutation rates.

Nature - 3 Sept 1998

Chen R Z, Pettersson U, Beard C, Jackson-Grusby L, Jaenisch R

Abstract excerpt

Genome-wide demethylation has been suggested to be a step in carcinogenesis. Evidence for this notion comes from the frequently observed global DNA hypomethylation in tumour cells, and from a recent study suggesting that defects in DNA methylation might contribute to the genomic instability of some colorectal tumour cell lines. DNA hypomethylation has also been associated with abnormal chromosomal structures, as...

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PMID: 9738504
DOI: 10.1038/25779

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