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Article

Uncoupling Kapbeta2 substrate dissociation and ran binding.

Biochemistry - 4 Jun 2002

Chook Yuh Min, Jung Astrid, Rosen Michael K, Blobel Günter

Abstract excerpt

Karyopherinbeta2 (Kapbeta2) imports a variety of mRNA binding proteins into the nucleus. Release of import substrates in the nucleus involves formation of a high-affinity Kapbeta2-RanGTP complex and concomitant dissociation of import substrates. The crystal structure of the Kapbeta2-RanGppNHp complex shows that Ran binds in the Kapbeta2 N-terminal arch and substrate most likely binds its C-terminal arch. The...

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Identifiers

PMID: 12033928
DOI: 10.1021/bi012122p

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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