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Article

Structural basis for SENP2 protease interactions with SUMO precursors and conjugated substrates.

Nature structural & molecular biology - 1 Dec 2006

Reverter David, Lima Christopher D

Abstract excerpt

SUMO processing and deconjugation are essential proteolytic activities for nuclear metabolism and cell-cycle progression in yeast and higher eukaryotes. To elucidate the mechanisms used during substrate lysine deconjugation, SUMO isoform processing and SUMO isoform interactions, X-ray structures were determined for a catalytically inert SENP2 protease domain in complex with conjugated RanGAP1-SUMO-1 or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17099700
DOI: 10.1038/nsmb1168

Genes

SENP2

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