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Article

A T42A Ran mutation: differential interactions with effectors and regulators, and defect in nuclear protein import.

Molecular biology of the cell - 1 Dec 1997

Murphy G A, Moore M S, Drivas G, Pérez de la Ossa P, Villamarin A, D'Eustachio P, Rush M G

Abstract excerpt

Ran, the small, predominantly nuclear GTPase, has been implicated in the regulation of a variety of cellular processes including cell cycle progression, nuclear-cytoplasmic trafficking of RNA and protein, nuclear structure, and DNA synthesis. It is not known whether Ran functions directly in each process or whether many of its roles may be secondary to a direct role in only one, for example, nuclear protein...

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Identifiers

PMID: 9398678
DOI: 10.1091/mbc.8.12.2591
PMCID: PMC25730

Genes

RCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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A T42A Ran mutation: differential interactions with effectors and regulators, and defect in nuclear protein import.PMID 9398678Read ↗

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The C terminus of the nuclear RAN/TC4 GTPase stabilizes the GDP-bound state and mediates interactions with RCC1, RAN-GAP, and HTF9A/RANBP1.Semantic proximity Read ↗

The role of the ran GTPase in nuclear assembly and DNA replication: characterisation of the effects of Ran mutants.Semantic proximity Read ↗

Destabilization of Ran C-terminus promotes GTP loading and occurs in multiple Ran cancer mutationsSemantic proximity Read ↗

Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.Semantic proximity Read ↗

Molecular interactions between the importin alpha/beta heterodimer and proteins involved in vertebrate nuclear protein import.Semantic proximity Read ↗

Engineered mutants in the switch II loop of Ran define the contribution made by key residues to the interaction with nuclear transport factor 2 (NTF2) and the role of this interaction in nuclear protein import.Semantic proximity Read ↗

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A RanBP1 mutation which does not visibly affect nuclear import may reveal additional functions of the ran GTPase system.Semantic proximity Read ↗

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