A T42A Ran mutation: differential interactions with effectors and regulators, and defect in nuclear protein import.

doi:10.1091/mbc.8.12.2591

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

A T42A Ran mutation: differential interactions with effectors and regulators, and defect in nuclear protein import.

Molecular biology of the cell - 1 Dec 1997

Murphy G A, Moore M S, Drivas G, Pérez de la Ossa P, Villamarin A, D'Eustachio P, Rush M G

Abstract excerpt

Ran, the small, predominantly nuclear GTPase, has been implicated in the regulation of a variety of cellular processes including cell cycle progression, nuclear-cytoplasmic trafficking of RNA and protein, nuclear structure, and DNA synthesis. It is not known whether Ran functions directly in each...

Topics

Amino Acid Substitution
Animals
Biological Transport
Carrier Proteins
Cell Cycle Proteins
Cell Membrane Permeability
DNA-Binding Proteins
Digitonin
GTPase-Activating Proteins
Guanine Nucleotide Exchange Factors
Guanosine Diphosphate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Guanosine Triphosphate

Hydrolysis

Liver

Molecular Chaperones

Mutation

Nuclear Envelope

Nuclear Pore Complex Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 9398678
DOI: 10.1091/mbc.8.12.2591
PMCID: PMC25730

Genes

RCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9398678-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A T42A Ran mutation: differential interactions with effectors and regulators, and defect in nuclear protein import.PMID 9398678Read ↗

Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing.Semantic proximity Read ↗

RanGAP1 induces GTPase activity of nuclear Ras-related Ran.Semantic proximity Read ↗

Characterization of the nuclear protein import mechanism using Ran mutants with altered nucleotide binding specificities.Semantic proximity Read ↗

The C terminus of the nuclear RAN/TC4 GTPase stabilizes the GDP-bound state and mediates interactions with RCC1, RAN-GAP, and HTF9A/RANBP1.Semantic proximity Read ↗

The role of the ran GTPase in nuclear assembly and DNA replication: characterisation of the effects of Ran mutants.Semantic proximity Read ↗

Destabilization of Ran C-terminus promotes GTP loading and occurs in multiple Ran cancer mutationsSemantic proximity Read ↗

Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.Semantic proximity Read ↗

Molecular interactions between the importin alpha/beta heterodimer and proteins involved in vertebrate nuclear protein import.Semantic proximity Read ↗

Engineered mutants in the switch II loop of Ran define the contribution made by key residues to the interaction with nuclear transport factor 2 (NTF2) and the role of this interaction in nuclear protein import.Semantic proximity Read ↗

Mutants in a yeast Ran binding protein are defective in nuclear transport.Semantic proximity Read ↗

A RanBP1 mutation which does not visibly affect nuclear import may reveal additional functions of the ran GTPase system.Semantic proximity Read ↗

GTP hydrolysis by Ran is required for nuclear envelope assembly.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.