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Article

Karyopherin-alpha2 protein interacts with Chk2 and contributes to its nuclear import.

The Journal of biological chemistry - 24 Oct 2003

Zannini Laura, Lecis Daniele, Lisanti Sofia, Benetti Roberta, Buscemi Giacomo, Schneider Claudio, Delia Domenico

Abstract excerpt

Chk2 is a nuclear protein kinase involved in the DNA damage-induced ataxia telangiectasia mutated-dependent checkpoint arrest at multiple cell cycle phases. Searching for Chk2-binding proteins by a yeast two-hybrid system, we identified a strong interaction with karyopherin-alpha2 (KPNA-2), a gen...

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Share to Nuclear Localization Signals
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12909615
DOI: 10.1074/jbc.M303304200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12909615-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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