Article
Transportins 1 and 2 are redundant nuclear import factors for hnRNP A1 and HuR.
RNA (New York, N.Y.) - 1 Apr 2004
Rebane Ana, Aab Alar, Steitz Joan A
Abstract excerpt
Several mRNA-binding proteins, including hnRNP A1 and HuR, contain bidirectional transport signals that mediate both their nuclear import and export. Previously, Transportin 1 (Trn1) was identified as a mediator of hnRNP A1 import, whereas the closely related protein Transportin 2 (Trn2) was shown to interact with HuR. Here we have investigated the subfamily of transportins that consists of Trn1 (or Kap beta2A)...
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