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Article

Defective nuclear import of Tpr in Progeria reflects the Ran sensitivity of large cargo transport.

The Journal of cell biology - 13 May 2013

Snow Chelsi J, Dar Ashraf, Dutta Anindya, Kehlenbach Ralph H, Paschal Bryce M

Abstract excerpt

The RanGTPase acts as a master regulator of nucleocytoplasmic transport by controlling assembly and disassembly of nuclear transport complexes. RanGTP is required in the nucleus to release nuclear localization signal (NLS)-containing cargo from import receptors, and, under steady-state conditions, Ran is highly concentrated in the nucleus. We previously showed the nuclear/cytoplasmic Ran distribution is disrupted...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23649804
DOI: 10.1083/jcb.201212117
PMCID: PMC3653351

Genes

KPNA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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