Article
Functional analysis of the hydrophobic patch on nuclear transport factor 2 involved in interactions with the nuclear pore in vivo.
The Journal of biological chemistry - 19 Oct 2001
Quimby B B, Leung S W, Bayliss R, Harreman M T, Thirumala G, Stewart M, Corbett A H
Abstract excerpt
Nuclear transport factor 2 (NTF2) is a small homodimeric protein that interacts simultaneously with both RanGDP and FxFG nucleoporins. The interaction between NTF2 and Ran is essential for the import of Ran into the nucleus. Here we use mutational analysis to dissect the in vivo role of the interaction between NTF2 and nucleoporins. We identify a series of surface residues that form a hydrophobic patch on NTF2,...
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