Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation screening analysis of the retinoblastoma related gene RB2/p130 in sporadic ovarian cancer and head and neck squamous cell cancer.

Molecular pathology : MP - 1 Jun 2002

Alvi A J, Hogg R, Rader J S, Kuo M J, Maher E R, Latif F

Abstract excerpt

AIMS: To investigate the involvement of the RB2/p130 gene in the pathogenesis of sporadic ovarian cancer in addition to head and neck squamous cell carcinoma (HNSCC). METHODS: Paired tumour and patient matched normal DNA samples from 43 sporadic ovarian tumours and 39 normal/tumour HNSCC DNA samples were screened. The mutation screen used polymerase chain reaction (PCR) amplification followed by single strand...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Squamous Cell
Share to DNA, Neoplasm

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Head and Neck Neoplasms

Share to Ovarian Neoplasms

Share to Phosphoproteins

Share to Polymorphism, Single-Stranded Conformational

Share to Retinoblastoma-Like Protein p130

Share to Retinoblastoma Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 12032225
DOI: 10.1136/mp.55.3.153
PMCID: PMC1187167

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation screening analysis of the retinoblastoma related gene RB2/p130 in sporadic ovarian cancer and head and neck squamous cell cancer.PMID 12032225Read ↗

Retinoblastoma-related gene RB2/p130 exons 19-22 are rarely mutated in glioblastomas.Semantic proximity Read ↗

Reduced transcription of the RB2/p130 gene in human lung cancer.Semantic proximity Read ↗

Loss of heterozygosity on chromosome 13q12-q14, BRCA-2 mutations and lack of BRCA-2 promoter hypermethylation in sporadic epithelial ovarian tumors.Semantic proximity Read ↗

Frequent Loss of pRb2/p130 in Human Ovarian CarcinomaSemantic proximity Read ↗

[Inactivation of BRCA1, BRCA2 and p53 genes in sporadic ovarian cancer].Semantic proximity Read ↗

Mutational analysis of TP53 and p21 in familial and sporadic ovarian cancer in Japan.Semantic proximity Read ↗

Somatic and germline mutations of the BRCA2 gene in sporadic ovarian cancer.Semantic proximity Read ↗

No germline mutations in CDKN2A (p16) in patients with squamous cell cancer of the head and neck and second primary tumours.Semantic proximity Read ↗

BRCA1 gene mutations in sporadic ovarian carcinomas: detection by PCR and reverse allele-specific oligonucleotide hybridization.Semantic proximity Read ↗

DNA aberrations at the retinoblastoma gene locus in human squamous cell carcinomas of the lung.Semantic proximity Read ↗

Mutation of the transforming growth factor-beta type II receptor gene is a rare event in human sporadic gastric carcinomas.Semantic proximity Read ↗

Mutation of the PTEN tumor suppressor gene is not a feature of ovarian cancers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.