Article
Reduced transcription of the RB2/p130 gene in human lung cancer.
Molecular carcinogenesis - 1 Nov 2003
Xue Jun Hu, Gemma Akihiko, Hosoya Yoko, Matsuda Kuniko, Nara Michiya, Hosomi Yukio, Okano Tetsuya, Kurimoto Futoshi, Seike Masahiro, Takenaka Kiyoshi, Yoshimura Akinobu, Toyota Minoru, Kudoh Shoji
Abstract excerpt
Reduced expression of the retinoblastoma gene (RB)2/p130 protein, as well as mutation of exons 19, 20, 21, and 22 of the same gene, has been reported in primary lung cancer. However, it has been suggested by other investigators that mutational inactivation and loss of the RB2/p130 gene and protein, respectively, are rare events in lung cancer. In order to determine the contribution and mechanisms of RB2/p130 gene...
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