Article
[Inactivation of BRCA1, BRCA2 and p53 genes in sporadic ovarian cancer].
Ceska gynekologie - 1 Oct 2008
Zikán M, Pohlreich P, Freitag P, Janousek M, Pavlista D, Fischerová D, Jancárková N, Sláma J, Pinkavová I, Cibula D
Abstract excerpt
OBJECTIVE: To analyze loss of heterozygosity (LOH), loss of expression and somatic mutations of BRCA1, BRCA2 and p53 genes in sporadic epithelial ovarian cancer samples. DESIGN: Original paper. SETTING: Oncogynecologic center, Clinic of Obstetrics and gynecology, First Faculty of Medicine, Charles University in Prague and General Teaching Hospital, Prague. MATERIAL AND METHODS: We used genomic DNA and total RNA...
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