Article
No germline mutations in CDKN2A (p16) in patients with squamous cell cancer of the head and neck and second primary tumours.
British journal of cancer - 2 Nov 2001
Jefferies S, Edwards S M, Hamoudi R A, A'Hern R, Foulkes W, Goldgar D, Eeles R
Abstract excerpt
There is increasing evidence that predisposition to some cancers has a genetic component. There is a high incidence of loss of heterozygosity on chromosome 9, in the region of tumour suppressor gene, CDKN2A (also known as p16), in sporadic squamous cell cancer of the head and neck (SCCHN). To investigate the possibility that CDKN2A may be involved in the inherited susceptibility to SCCHN, the 3 coding exons of...
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