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Article

Mutational analysis of TP53 and p21 in familial and sporadic ovarian cancer in Japan.

Gynecologic oncology - 1 Feb 2006

Amikura Takayuki, Sekine Masayuki, Hirai Yasuo, Fujimoto Seiichiro, Hatae Masayuki, Kobayashi Iwao, Fujii Tsuneo, Nagata Ichiro, Ushijima Kimio, Obata Koshiro, Suzuki Mitsuaki, Yoshinaga Mitsuhiro, Umesaki Naohiko, Satoh Shinji, Enomoto Takayuki, Motoyama Satoru, Nishino Koji, Haino Kazufumi, Tanaka Kenichi

Abstract excerpt

OBJECTIVE: To investigate whether somatic mutations in cell cycle checkpoint genes, TP53 and p21, are involved in the development of ovarian cancer with or without BRCA1 germline mutation. METHODS: We analyzed somatic genetic alterations of TP53 and p21 in 46 ovarian cancer patients with BRCA1 germline mutations and 93 sporadic patients, using direct sequencing for the entire coding sequences in TP53 and p21....

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Source

Identifiers

PMID: 16337994
DOI: 10.1016/j.ygyno.2005.09.010

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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