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Article

Frequent Loss of pRb2/p130 in Human Ovarian Carcinoma

1 May 2004

Abstract excerpt

PURPOSE: RB2/p130, a member of the retinoblastoma gene family, maps to human chromosome 16q12.2, a region in which deletions have been found in several human neoplasms including breast, prostatic, and ovarian carcinoma. We sought to evaluate pRb2/p130 protein expression and function in ovarian carcinoma. EXPERIMENTAL DESIGN: pRb2/p130 expression was detected by immunohistochemical and Western blot analyses in 45...

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PMID: 15131049
DOI: 10.1158/1078-0432.ccr-03-0524

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Frequent Loss of pRb2/p130 in Human Ovarian CarcinomaPMID 15131049Read ↗

Mutations in the retinoblastoma-related gene RB2/p130 in lung tumors and suppression of tumor growth in vivo by retrovirus-mediated gene transfer.Semantic proximity Read ↗

Activity of the Retinoblastoma Family Proteins, pRB, p107, and p130, during Cellular Proliferation and DifferentiationSemantic proximity Read ↗

Loss of the retinoblastoma protein-related p130 protein in small cell lung carcinomaSemantic proximity Read ↗

Disruption of the p16/Cyclin D1/Retinoblastoma Protein Pathway in the Majority of Human Hepatocellular CarcinomasSemantic proximity Read ↗

Reduced transcription of the RB2/p130 gene in human lung cancer.Semantic proximity Read ↗

Loss of expression of the p16 tumor suppressor gene is more frequent in advanced ovarian cancers lacking p53 mutations.Semantic proximity Read ↗

Role of Retinoblastoma Protein Family (Rb/P105 And Rb2/P130) Expression in the Hystopathological Classification of Borderline Ovarian TumorsSemantic proximity Read ↗

Mutation screening analysis of the retinoblastoma related gene RB2/p130 in sporadic ovarian cancer and head and neck squamous cell cancer.Semantic proximity Read ↗

Abnormal expression of cell cycle regulatory proteins in ductal and lobular carcinomas of the breast.Semantic proximity Read ↗

Genetic alterations at the nuclear localization signal of the RB2/p130 gene occur in lymphoid tumor but not in osteosarcoma cell lines.Semantic proximity Read ↗

Gene-expression analysis identifies novel RBL2/p130 target genes in endemic Burkitt lymphoma cell lines and primary tumors.Semantic proximity Read ↗

Loss of the retinoblastoma tumor-suppressor gene in parathyroid carcinoma.Semantic proximity Read ↗

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