Article
BRCA1 gene mutations in sporadic ovarian carcinomas: detection by PCR and reverse allele-specific oligonucleotide hybridization.
Clinical chemistry - 1 Jul 1999
Tong D, Stimpfl M, Reinthaller A, Vavra N, Müllauer-Ertl S, Leodolter S, Zeillinger R
Abstract excerpt
BACKGROUND: Although germline mutations in BRCA1 play a central role in familial breast and ovarian cancers, to date, no somatic mutations in BRCA1 have been reported in sporadic breast cancer, and only five somatic mutations have been identified in the sporadic ovarian carcinomas. Because loss of heterozygosity appears frequently at the BRCA1 locus in nonfamilial breast and ovarian carcinomas, we searched for...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.