Article
DNA aberrations at the retinoblastoma gene locus in human squamous cell carcinomas of the lung.
Oncogene - 1 Jan 1994
Sachse R, Murakami Y, Shiraishi M, Hayashi K, Sekiya T
Abstract excerpt
We detected DNA aberrations at the RB locus in surgical specimens of human primary non-small cell lung carcinoma by single-strand conformation polymorphism analysis of polymerase chain reaction products amplified from regions of exons 2 to 27 including parts of the flanking intron sequences. Detection of nucleotide sequence polymorphism revealed loss of heterozygosity in six of eight informative cases among 13...
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